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2003 5
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284 results

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Page 1
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H. Driehuis E, et al. Cancer Discov. 2019 Jul;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522. Epub 2019 May 3. Cancer Discov. 2019. PMID: 31053628
Organoid models of gastrointestinal cancers in basic and translational research.
Lau HCH, Kranenburg O, Xiao H, Yu J. Lau HCH, et al. Nat Rev Gastroenterol Hepatol. 2020 Apr;17(4):203-222. doi: 10.1038/s41575-019-0255-2. Epub 2020 Feb 25. Nat Rev Gastroenterol Hepatol. 2020. PMID: 32099092 Review.
Historically, the mechanisms of tumour initiation and progression in the gastrointestinal tract have been studied using cancer cell lines in vitro and animal models. Traditional cell culture methods are associated with a strong selection of aberrant genomic variants that n …
Historically, the mechanisms of tumour initiation and progression in the gastrointestinal tract have been studied using cancer cell lines in …
Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice.
Küçükköse E, Heesters BA, Villaudy J, Verheem A, Cercel M, van Hal S, Boj SF, Borel Rinkes IHM, Punt CJA, Roodhart JML, Laoukili J, Koopman M, Spits H, Kranenburg O. Küçükköse E, et al. J Immunother Cancer. 2022 Dec;10(12):e005345. doi: 10.1136/jitc-2022-005345. J Immunother Cancer. 2022. PMID: 36543378 Free PMC article.
The mechanisms underlying this site-specific benefit of ICB are unknown. METHODS: We created a novel model for spontaneous multiorgan metastasis in MSI-H CRC tumors by transplanting patient-derived organoids (PDO) into the cecum of humanized mice. ...
The mechanisms underlying this site-specific benefit of ICB are unknown. METHODS: We created a novel model for spontaneous multiorgan …
Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer.
Strating E, Verhagen MP, Wensink E, Dünnebach E, Wijler L, Aranguren I, De la Cruz AS, Peters NA, Hageman JH, van der Net MMC, van Schelven S, Laoukili J, Fodde R, Roodhart J, Nierkens S, Snippert H, Gloerich M, Rinkes IB, Elias SG, Kranenburg O. Strating E, et al. Front Immunol. 2023 May 16;14:1053920. doi: 10.3389/fimmu.2023.1053920. eCollection 2023. Front Immunol. 2023. PMID: 37261365 Free PMC article.
Here, we aimed to generate a model system for studying the interaction between cancer cells and CAFs and their effect on immune-related cytokines and T cell proliferation. METHODS: CAFs were isolated from colon cancer liver metastases and were immortalized to prolong lifes …
Here, we aimed to generate a model system for studying the interaction between cancer cells and CAFs and their effect on immune-related cyto …
Potato Protein Ingestion Increases Muscle Protein Synthesis Rates at Rest and during Recovery from Exercise in Humans.
Pinckaers PJM, Hendriks FK, Hermans WJH, Goessens JPB, Senden JM, VAN Kranenburg JMX, Wodzig WKHW, Snijders T, VAN Loon LJC. Pinckaers PJM, et al. Med Sci Sports Exerc. 2022 Sep 1;54(9):1572-1581. doi: 10.1249/MSS.0000000000002937. Epub 2022 Apr 22. Med Sci Sports Exerc. 2022. PMID: 35438672 Free PMC article. Clinical Trial.
This study compares muscle protein synthesis rates after the ingestion of 30 g potato protein versus 30 g milk protein at rest and during recovery from a single bout of resistance exercise in healthy, young males. METHODS: In a randomized, double-blind, parallel-group desi …
This study compares muscle protein synthesis rates after the ingestion of 30 g potato protein versus 30 g milk protein at rest and during re …
Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification.
Millen R, De Kort WWB, Koomen M, van Son GJF, Gobits R, Penning de Vries B, Begthel H, Zandvliet M, Doornaert P, Raaijmakers CPJ, Geurts MH, Elias SG, van Es RJJ, de Bree R, Devriese LA, Willems SM, Kranenburg O, Driehuis E, Clevers H. Millen R, et al. Med. 2023 May 12;4(5):290-310.e12. doi: 10.1016/j.medj.2023.04.003. Med. 2023. PMID: 37178682 Free article.
Head and neck cancer (HNC) is a collective term used for multiple tumor types including squamous cell carcinomas and salivary gland adenocarcinomas. METHODS: Organoids were established from HNC patient tumor tissue and characterized using immunohistochemistry and DNA seque …
Head and neck cancer (HNC) is a collective term used for multiple tumor types including squamous cell carcinomas and salivary gland adenocar …
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
Pemafibrate, a selective peroxisome proliferator-activated receptor alpha modulator, reduces triglyceride levels and improves other lipid levels. METHODS: In a multinational, double-blind, randomized, controlled trial, we assigned patients with type 2 diabetes, mild-to-mod …
Pemafibrate, a selective peroxisome proliferator-activated receptor alpha modulator, reduces triglyceride levels and improves other lipid le …
Protein Ingestion before Sleep Increases Muscle Mass and Strength Gains during Prolonged Resistance-Type Exercise Training in Healthy Young Men.
Snijders T, Res PT, Smeets JS, van Vliet S, van Kranenburg J, Maase K, Kies AK, Verdijk LB, van Loon LJ. Snijders T, et al. J Nutr. 2015 Jun;145(6):1178-84. doi: 10.3945/jn.114.208371. Epub 2015 Apr 29. J Nutr. 2015. PMID: 25926415 Free article. Clinical Trial.
OBJECTIVE: Here we assessed the impact of dietary protein supplementation before sleep on muscle mass and strength gains during resistance-type exercise training. METHODS: Forty-four young men (22 1 y) were randomly assigned to a progressive, 12-wk resistance exercise trai …
OBJECTIVE: Here we assessed the impact of dietary protein supplementation before sleep on muscle mass and strength gains during resistance-t …
Pre-sleep Protein Ingestion Increases Mitochondrial Protein Synthesis Rates During Overnight Recovery from Endurance Exercise: A Randomized Controlled Trial.
Trommelen J, van Lieshout GAA, Pabla P, Nyakayiru J, Hendriks FK, Senden JM, Goessens JPB, van Kranenburg JMX, Gijsen AP, Verdijk LB, de Groot LCPGM, van Loon LJC. Trommelen J, et al. Sports Med. 2023 Jul;53(7):1445-1455. doi: 10.1007/s40279-023-01822-3. Epub 2023 Mar 1. Sports Med. 2023. PMID: 36857005 Free PMC article. Clinical Trial.
OBJECTIVE: We aimed to assess the impact of casein and whey protein ingestion prior to sleep on mitochondrial and myofibrillar protein synthesis rates during overnight recovery from a bout of endurance-type exercise. METHODS: Thirty-six healthy young men performed a single …
OBJECTIVE: We aimed to assess the impact of casein and whey protein ingestion prior to sleep on mitochondrial and myofibrillar protein synth …
Next Generation Prokaryotic Engineering: The CRISPR-Cas Toolkit.
Mougiakos I, Bosma EF, de Vos WM, van Kranenburg R, van der Oost J. Mougiakos I, et al. Trends Biotechnol. 2016 Jul;34(7):575-587. doi: 10.1016/j.tibtech.2016.02.004. Epub 2016 Mar 2. Trends Biotechnol. 2016. PMID: 26944793 Review.
284 results